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Testerone Replacement Therapy for Men with Metabolic Syndrome
Metabolic syndrome (MS) is associated with low serum testosterone levels, as demonstrated by epidemiological and interventional approaches. Coversely, low testosterone levels induce MS. These mechanisms reinforce one another and induce a visious cycle. Testosterone sunstritution mechanisms of MS by by verious pathways. Typical clinicalsigns and symptoms, together with treatment history can identifly candidates for testosterone therapy test, and potential testosterone replacement therapy (TRT). The major goal of TRT is to replace testoterone at levels as close to physiological concentration as possible. Testosterone replacement is usually for long duration, and patient compliance is very importamt. Therefore, the patient must be involved in the selection of testosterone preparation type Transdermal testosterone preparation type Transderrmal testosterone gel produces attactive pharmacokinetic serum testosterone profiles ofters greater dose flexibility and can be discontinued immediately in case of complications; it has been recommender for elderly males.
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