Angiopoietin Like Protein 3 (Angeptl3), Fatty Acid Binding Protein 4 (FABP4) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Among Indonesia Obese non Diabetic Males | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Angiopoietin Like Protein 3 (Angeptl3), Fatty Acid Binding Protein 4 (FABP4) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Among Indonesia Obese non Diabetic Males

Yani Lina - Personal Name; Gatot S. Lawrence - Personal Name; Andi Wijaya - Personal Name; Suryani As"ad - Personal Name;

Aim To reveal the correlation between Angptl3, FABP4 and HOMA-fR among Indonesian obese non diabetic males. Methods This is a cross sectional study with 133 obese non diabetic males volunteers (characterized by waist circumference> 90 cm; fasting blood glucose < J 26 mgldL; and no diabetic specific symptoms) age between 30- 60 years which was done in Jakarta, Indonesia. We measured biochemical markers such as Angptl3, FABP4, FFA, fasting insulin and fasting glucose. We also measured weight, height, waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Correlation between each marker was measured using Pearson and Speannan's analysis.
Results Pearson and Spearman's correlation analysis showed significant positive correlation between Angpt13 and FABP4 (r ~ 0.319; p ~ 0,000), Angptl3 and FFA (r ~ 0.171; r ~ 0.049), FABP4 and HOMA-JR (r ~ 0.202; P ~ 0.019), HA and FABP4 (r ~ 0.506; P ~ 0.000), WC and HOMA-IR (r ~ 0,323; p ~ 0.000), WC and FABP4 (r ~ 0.387; P ~ 0.000), Body Mass Index (BMI) and HOMA-IR (r ~ 0.270; P ~ 0,002), BMI and FABP4 (r ~ 0.362; P ~ 0,000).
Conclusion This study showed positive significant correlations between Angpt\3-FABP4, AngptI3-FFA, FFA-FABP4 and FABP4-HOMA-IR We suggest that Angptl3 can activate lipolysis in adipose tissue (through its correlation with FABP4), and Angpt13 concentration is related to insulin resistance risk among Indonesian obese non diabetic males. (Med J Indones 2010; 19: 185-90)

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Location name is not set Medical Journal of Indonesia;19(3)2010:185-190

A0001572

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Series Title: -
Call Number: Medical Journal of Indonesia;19(3)2010:185-190
Publisher: Jakarta : Fculty of Medicine University of Indonesia., 2010
Collation: 5p.
Language
ISBN/ISSN: 0853--1773
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): obesity
INSULIN RESISTANCE
HOMEOSTATIS
FATTY ACID -BINDING PROTEIN
Specific Detail Info: -
Statement of Responsibility: -

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