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Pain Stimulated by Electric Foot Shock to Liver and Spleen Microscopic Immunological Respons Features (BALB/c Micc Experimental Study)

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Background: Pain affects immune system by decreasing type l-lmmune response that might be seen on microsc0f,ic features of liver and spleen. The objective of the study is to prove the effect of pain to immune response that confirmed by liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells of Balble mice suffered from pain.
Method: This study adapts Laboratory Experimental and Post-Test Only Control Group Design. The samples were 12 female BALB/C mice (average weight 21.88 (SD=I.75) grams and divided into two groups. The control group (e) received no other additional treatment. The Pain (P) group received pain stimulated by Electric Foot Shock (EFS) 1-3 mA at day 12th to 2/",'. All groups were intravenously injected with 10-1 live L. manocytogenes at day 2 l" and sacrificed at day 26th by chloroform anaesthesia. Then, liver microabscess formation. hepatocytes destruction and spleen multinucleated giant cells were counted. Data were analyzed by independent Hest (significant if p

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Series Title

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Call Number

Media Medika Indonesiana;44(1)2010:27-32

Publisher

Semarang : FK Universitas Diponegoro Semarang., 2010

Collation

5p.

Language

English

ISBN/ISSN

0126-1762

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Media Type

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Carrier Type

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Edition

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Subject(s)

pain
MACROEPHAGES

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