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Low Class Ib (HLA-G/Qa-2) HMC Protein Expression Agains Hsp-70 and VCAM-1 Profile on Preeclampsia An Observation on Experimental Animal Mus Mus Musculus with Endothelial Dysfunction Model

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Objective: To analyze the expression ofMHC class Ib Qa-2 pro¬tein (homologue to HLA-G in human), Hsp-70, and VCAM-I in tro¬phoblast cells of preeclampsia and control using endothelial dys¬function model on Mus Musculus.
Method: Design of study is experimental study. Pregnant mice was treated with anti-Qa-Z. Hsp-70 and VCAM-l expressions of trophoblast cells was assessed on week I, Il, and Ill.
Result: Negative Qa-2 expression was achieved after admini-stration of 40ng anti Qa-2 on the fifth day of pregnancy. The Hsp-70 and VCAM-I expressions in negative Qa-2 mice (preec1ampsia) was higher compared with those of positive Qa-2 mice (normal pregnancy) on week I, Il and Ill.
Conclusion: Low Qa-2 and high of HSP-70 and VCAM-l ex-pression might be useful for prediction of preeclampsia or endothe¬lial dysfunction.
[Indones J Obstet Gynecol 2010; 34-3: 103-7]

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Obstetric dan Ginekologi Indonesia;34(3)20

Penerbit

Jakarta : Indonesia Society of Obstetrics and Gynecology., 2010

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

0303-7924

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

pre-eclampsia
proteins
ENDOTHELIUM

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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