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Asosiasi dan Disosiasi Insulin-Antibodi Insulin pada Pasien Sindrom autoimun Insulin

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The insulin autoimmune syndrome ( !AS ) is characterized by the autoantibodies formation in patient without previous insulin usage. Patient affected by IAS usually developed hyperglycemia followed by hypoglycemia after meal due to association of insulin to its antibody and dissociation of insulin from insulin-insulin antibodies complexes. This study was carried out by evaluation of the changes of the free immunoreactive insulin (FIRI) concentration and the total immunoreactive insulin (TIRI) concentration. Insulin antibody and blood sugar during 75 g oral glucose tolerance test (75 g OGTT) also evaluated. There were two distinct time courses could be identified during the OGTT. The insulin antibody concentration gradually decreased from 54% to 45% at 120 minutes. That change indicates consumption of the antibody or association of the insulin to its antibody, results in the increase of bound insulin or TIRI at the same time. The blood sugar increased to 200 mg% in 60 minutes due to relativity insufficient of FIRI to supress blood sugar elevation after OGTT. After 120 minutes of OGTT the concentrations of TIRI and the insulin antibodies were returned to the basal level and these changes were strongly indicated the dissociation of the insulin-insulin antibodies complexes. Blood sugar was decreased to 33 mg% at 240 minutes, may be due to the relativity excess of FIRI released from insulin-insulin antibodies complexes. These data indicated that association of the insulin to its antibody result in hyperglycemia 60 minutes after OGTT and dissociation of the insulin-insulin antibodies complexes result in hypoglycemia 240 minutes after OGTT.

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Detail Information

Series Title

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Call Number

Majalah FK.Universitas Kristen Indonesia;37(1)2010

Publisher

Jakarta : FK Universitas Kristen Indonesia., 2010

Collation

4p.

Language

ISBN/ISSN

0216-4752

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

INSULIN ANTIBODIES

Specific Detail Info

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