A Comparsion of 5 or 7 Days of Rebeprazole Tripe Therapy for Eradication of Helicobacter Pylori | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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A Comparsion of 5 or 7 Days of Rebeprazole Tripe Therapy for Eradication of Helicobacter Pylori

Ari F. Syam - Personal Name; Siti Nurdjanah - Personal Name; Abdul A Rani - Personal Name; MardaniAbdulah - Personal Name;

Aim A combination of PPI and 1000 mg amoxicillin/500 mg clarithromycin twice daily for 2 weeks has been proven effective in the eradication of H. pylori. Most studies suggested that treatment for 7 and 10 days may be equally effective. Few data are available on the effi cacy of 5-day triple therapy. Aim of this study was to compare 5-day and 7-day rabeprazole triple therapy for eradication of H. pylori infection. Methods We prospectively studied 60 consecutive H. pylori-infected patients who came to hospitals in six centres in Indonesia and who underwent upper endoscopy and biopsy. H. pylori infection was confi rmed if two rapid urease tests (Pronto Dry) and histology or urea breath test were positive. Patients were assigned to either an open-labelled 5-day or 7-day course of oral amoxicillin 1000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 10 mg b.i.d. (RAC).Four weeks after therapy, all patients had a repeated UBT for evaluation of the presence of H. pylori. Results Of the 60 patients (42 males and 18 females) with mean age (± SD) 47.63 ± 13.93 years, range 21–74 years, 25 patients (41.7%) had 5-day treatment and 35 patients (58.3%) had 7-day treatment. With 5-day treatment, 18 patients (72%) and with 7-day treatment 32 patients (91.4%) became negative for H. pylori infection. The eradication failure was found on 7 patients (28.0%) in 5-day reatment and 3 patients (8.6%) in 7-day treatment. Conclusions The study showed that the eradication of H. pylori infection by triple rabeprazole-based treatment in 7-day is still better than in 5-day.

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Location name is not set Medical Journal of Indonesia;19(2):113-117

A001321

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Series Title: -
Call Number: Medical Journal of Indonesia;19(2)2010:113-117
Publisher: Jakarta : Faculty of Medicine Unversity of Indonesia., 2010
Collation: 4p.
Language: English
ISBN/ISSN: 0853-1773
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Content Type: -
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Edition: -
Subject(s): helicobacter pylori
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