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Hipertensi Arteri Pulmonalis
Pulmonary arterial hypertension (P AH) is a syndrome due to restricted flow through the pulmonary arterial circulation. It is resulting in the increase of pulmonary vascular resistance and ultimatelyin right heart failure. Pulmonary arterial hypertension considered as a rare disease. Multiple pathogenic pathways have beenimplicated in the development of P AH, including those at themolecular and the genetic levels. Furhermore, it is known that the imbalance of proliferation and apoptosis plays an important role in the pathogenesis of P AH. Microscopically the result of the imbalance between cell proliferation and apopotosis is ~pears in the smooth muscle, endothelialcells and the adventitia of the blood vessels. The imbalance in the vasoconstriction-vasodilatationmilieu has served as the basic for the current medical therapy.
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