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Pengembangan Formulasi Radiofarmaka Siprofioksasin dalam Wadah Tunggal (Development of Ciprofloxacin Radiopharmaceutical Formulation in Single Vial)

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Bacterial infection diseases is the greatest death causes in Indonesia.
Detection of the deep-seated infection location caused by the gram positive and gram negative bacteries could be done with nutlear technique using 99mrc_ ciprofloxacin radiopharmaceutical. In order to fulfill the necessity of this radiopharmaceutical, the development of formulation in single vial based on Sn(II) chloride and tartaric acid instead of Sn(II) tartrat has been carried out. The aim of this investigation is to obtained the optimum condition of 99rl'l"J"c-ciprofloxacin preparation with maximum labelling efficiency. Several parameters influencing the labelling process of 99m-rc-ciprofloxacin such as the amount of tartaric acid, pH of the reaction, the amount of Sn(II) ion as a reducing agent and the incubation time has been studied. The labelling efficiency and the radiochemical purity of 99mrc-ciprofloxacin were determined by double chromatography system using Whatman I/methyl ethyl keton to determine the free 99mTc-pertechnetate and ITLC¬SG/(ethanol:water:ammonia = 2:5:1) to separate the free 99"'Tc-reduced.

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia;21(2)2010:139-149

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2010

Collation

10p.

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ciprofloxacin
RADIO PHARMACEUTICALS

Specific Detail Info

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