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Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok

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Cigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolitc in Pleurotus ostreatus such us fcnol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels ofmalondialdehyde (MDA) and surface density (SlY) after exposure to cigarette smoke. The research used completed randomized design and a-tocopherol was used as control group. The dose ofPleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for J 0 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (SlY) were observed on day 11 th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MD A (0.4667+0.22295 nm/ml.), as good as that of a-tocopherol (0,7467+0,24089 nm/mL). Ethanol extract also prevented the reduction oflung SlY (0.62283+0.4793) and it's effect was better from a-tocopherol (0.54683±0.39832), p~

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Series Title

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Call Number

Majalah Kedokteran Bandung;42(4)2010:195-202

Publisher

Bandung : FK. Universitas Padjadjaran Bandung., 2010

Collation

7p.

Language

ISBN/ISSN

0126-074X

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Edition

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Subject(s)

smoke
MOLONDIALDEHYDE
ANTIORIDANTS

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