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Polimorfisme FokI, BsmI, ApaI, dan TaqI Gen Reseptor Vitamin D pada Kejadian Tuberkulosis Anak

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Tuberculosis (TB) is a infection disease caused by Mycobacterium tuberculosis. Mycobacterium tuberculosis itself is not the only factor ofTB. Polymorphism of vitamin D receptor (VDR) gene is important on the susceptibility of TB. The aim was to find out the role of Fokl, Bsml, Apal, and TaqI VDR gene polymorphism on child TB. The observational analytic study with case control design was done in RSVP Dr. Hasan Sadikin Bandung and RSU Cibabat Cimahi, May 2008-March 2009. The subjects consisted of 42 children each for case (TB) and control (non TB) group, enrolled by consecutive sampling. The blood was analyzed for polymorphism of Fokl, Bsml, Apal, and Taql VDR gene. Chi-square test, Mann-Whitney test, to calculate odds ratio (OR) and 95% confidence interval (Cl) were used. The incidence of Fokl VDR gene polymorphism in TB case group was 66.7% and 40.5% in control group (p~O.O 16), OR (95% Cl): 2.94 (1.21-7.16). The Fokl VDR gene polymorphism for TB group was 2.94 times greater than that for control group; while for BsmI, ApaI, and Taql VDR gene polymorphism, there was no significant difference between TB case and control (p>0.05).lt is concluded, Fokl VDR gene polymorphism is a risk factor of child TB. [MKB. 2010;42(4):187-94].

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Detail Information

Series Title

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Call Number

Majalah Kedokteran Bandung;42(4)2010:187-194

Publisher

Bandung : FK. Universitas Padjadjaran Bandung., 2010

Collation

7p.

Language

ISBN/ISSN

0126-074X

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

TUBERCULOSIS
POLYMORPHISM, GENETIC
VITAMIN D

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