Text

Ekspresi Reseptor-Estrogen pada Ademona Pleomorfik Parotis

---

Parotid pleomorphic adenoma (PPA) is a benign turnor frequently found in parotid salivary gland. This tumor has various biological behaviors including recurrence after surgery, ability to transform into the malignant form, and occasionally, metastasizes to lymph nodes or other organs. For this PPA turnor, it is appropriate to look for alternative therapy forms other than surgery which is assumed to be the cause of the high tumor recurrence. Other alternatives may include hormonal therapy that needs baseline data on estrogen-receptor expression by PPA tumor cells. To collect the baseline data, a laboratory experimental retrospective study on immunohistochemical study using LsABIlabelled strepavidine-biotine technique of estrogen receptor (ER) receptor on 50 PPA tumor samples at the Anatomic Pathology Department of the Faculty of Medicine, Padjadjaran UniversitylHasan Sadikin General Hospital during 1998-1999 has been conducted. The observation is focused on the grouping of ER irnrnunoexpression level spread by PPA turnor cells: O~negative; + I =focal (>20%); + 2~heterogeneous (20-50%); and +3~diffuse (>50% immunoreactive tumor cells). The results showed that 40/50 PPA tumor samples (80%) were immunoreactive towards ER with an immunoexpression composition of: 67.5% heterogeneous (27/40) and 32.5% diffuse (13/40). A homogenous smear pattern was observed in turnor cell nucleus. Ten cases showed negative results (8 cases negative and 2 cases focal). The positive PPA tumor tissue components included ductal Itubuloductal epithels, mixomatose and hypercellullarareas.ln conclusion, PPA tumor plays the role as target ofestrogen hormone and there is a high possibility that it is responsive to hormonal therapy. [M KB. 201 0;42(4): 181-6].

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

Majalah Kedokteran Bandung, 42(4)2010: 181-186

Penerbit

Bandung : FK Universitas Padjadjaran., 2010

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

0126-074X

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

RECEPTORS, ESTROGEN
PAROTID NEOPLASMS
ADENOMA, PLEOMORPHIC

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar