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Kolerasi Ekspresi Protein Deleted in Colorectal Cancer (DCC) dengan Keganasan Kolorektal Stadium II dan III

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Deleted in colorectal cancer (DCC) gene is one of the tumor supressor genes which play a role in colorectal pathogenesis. Mutation of this DCC gene was found in approximately 70% cases and the absence ofDCC protein expression give the poor prognosis. The aim of the study was to evaluate whether the expression ofDCC protein had a correlation with metastasis probability of the stage Il and III colorectal cancer. This was a cross-sectional study and data were obtained retrospectively. The data consisted of 38 colorectal carcinoma samples in second and third stadium, 19 samples in each stadium, during the period of May to August 2007. We perfomed imunohistochemistry examination. On this study, the youngest was 18 years old and the oldest was 83 years old. According to gender, 18 samples (47.4%) were male and 20 samples (52.6%) were female. All samples in stage II stadium gave expression of the DCC protein and there were 5 samples (13.16%) with stadium 1II didn't give expression. From statistical analysis, chi square 5.758 and the p-value was 0.016 (p < 0.05). We can conclude that there is a correlation between the colorectal carcinoma stadium and the expression ofDCC protein. [MKB. 20] 0;42( I): 12-6].

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Majalah Kedokteran Bandung, 42(1)2010: 12-16

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Bandung : FK Universitas Padjadjaran., 2010

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4p.

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0126-074X

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