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Serum estradiol levels and bone mineral density in postmenopausal women

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Postmenopausal women are at high risk of disease, such as coronary heart disease, stroke, mal ignancies, dementia and osteoporosis. Th is is due to decreased levels ofestrogen/estradiol, produced mainly in the ovaries, leading to reduced bone mineral density (BM D), which is the gold standard for diagnosis of osteoporosis. The purpose of the present study was to determine the relationship between serum estradiol levels and BMD in postmenopausal women. The study, which was of cross-sectional design, involved 184 postmenopausal women meeting the inclusion criteria, viz. healthy postmenopausal women aged between 47 and 60 years having taken no hormonal medications in the previous 3 years. The subjects were assessed for anthropometric and biochemical characteristics, including BMD and serum estradiol levels. BMO was measured at the lumbar spine, right femoral neck and at the distal radius by the dual-energy X-ray absorptiometry (OXA) instrument. The mean serum estradiol concentration was 7.54 ± 4.65 pg/ml, while in 49.5% of the subjects the estradiol concentration was s 5 pgzml. In postmenopausal women with estradiol concentrations of> 5 pg/ml, a significant positive relationship was found between BMD and the T¬scores for the femoral neck. Thus the higher the serum estradiollevels, the higher the BMD values for femoral neck region. In conclusion, the results of this study point to estradiol levels as a major factor in determining the BMD values in postmenopausal women.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Universa Medicina, 29(2 )2010:90-95

Penerbit

Jakarta : Trisakti University., 2010

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

1907-3062

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BONE DENSITY
POSTMENOPAUSE
ESTRADIOL

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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