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Peningkatan Kolesterol pada Tikus Putih (Rattus Norvegicus) Akibat Diet Tinggi Lemak Jenuh (Improvement of Blood Cholesterol on Rat (Rattus novergicus) Induced by High Saturated Fat Diet)

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Diet tinggi lemak rantai jenuh ikut berperan sebagai penyebab meningkatnya prevalensi obesitas dan sindroma metabolik A high saturated fatty chains diet play a role in the increasing prevalence of obesity and metabolic syndrome. Profil lipid darah merupakan indikator yang penting untuk mengetahui faktor resiko kelainan kardiovaskuler. Penelitian ini bertujuan untuk mengetahui pengaruh diet tinggi lemak jenuh terhadap po la peningkatan kolesterol darah Blood lipid profile is an important indicator to determine the risk factors of cardiovascular disorders. This study aims to determine the effect of a high saturated fats diet increase blood cholesterol patterns. Pemberian diet tinggi lemak dilakukan secara ad libitum se lama sepuluh minggu kemudian dilakukan pengukuran berat badan, dan pemeriksaan kadar Kolesterol Total secara serial setiap minggu. Providing high-fat diet ad libitum conducted for ten weeks and then measured body weight and examination of Total Cholesterol levels in serial each week. Penelitian ini merupakan penelitian eksperimental murni dengan the randomized separated pretest postest control group design. Rattus norvegiscus galur Wistar sebanyak 44 ekor dibagi secara random menjadi dua kelompok yaitu kelompok kontrol dengan diet standar dan kelompok perlakuan dengan diet tinggi lemak selama sepuluh minggu. This research is true experimental with the randomized experimental pretest posttest control group separated design. 44 male Rattus norvegiscus strain Wistar were divided randomly into two groups: control group with standard diet and treatment groups with a high-satureted fat diet for ten weeks. Tiap minggu dilakukan pengukuran berat badan dan pemeriksaan kadar kolesterol darah. Each week body weight and blood cholesterol was measured. Analisis data menggunakan independent sample t test dan analisis korelasi Pearson. Analysis of data using independent sample t test. Hasil pengukuran praperlakuan didapatkan re rata berat badan kelompok kontrol 159.5 ± 25,6 gram dan kelompok perlakuan 161.5 ± 27.7 gram. The measurement results before treatment found that mean body weight in control and treatment group was 159.5 ± 25.6 9 and 161.5 ± 27.7. Kadar Kolesterol kontrol 87.25 ± 5.74 mg/dl dan kelompok perlakuan 83.5 ± 6.61 mg/dl. Cholesterol in control and treatment group was 87.25 ± 5.74 mg / dl and 83.5 ± 6.61 mg / dl. Peningkatan kadar kolesterol darah mulai terjadi pada minggu ke-2 pemberian diet tinggi lemak walaupun tidak menunjukkan perbedaan yang bermakna. Increased blood cholesterol levels began to occur at week 2 of high-fat diet, although did not show significant difference. Sebagai kesimpulan, diet tinggi lemak selama 10 minggu menyebabkan terjadinya peningkatan kadar kolesterol plasma namun tidak cukup untuk menyebabkan perbedaaan yang bermakna. In conclusion, high-fat diet for 10 weeks resulted in increased plasma cholesterol levels but not enough to cause a significant difference.

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Series Title

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Call Number

Majalah Ilmu Faal Indonesia;9(3)2010:156-161

Publisher

Surabaya : Ikatan Ahli Ilmu Faal Indonesia., 2010

Collation

5p.

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ISBN/ISSN

0215-1995

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Edition

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Subject(s)

dietary fats
rats
CHOLESTEROL, DIETARY

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