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Ko-Prosesing Pati Garut-Kitosan secara Spray Drying (Co Procesing of the Arrowroot-Chitosan by Spray Drying)

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Starch is one of the most widely used excipient in the manufacture of solid dosage forms. One of few problems associated with starch is its poor flow ability so can't used as excipient in direct compression tablet. The purpose of these studies was to develop of the arrowroot starch for use as excipient in direct compression tablet. The arrowroot starch was co-processing with chitosan by spray drying. The suspension of arrowroot starch-chitosan for feed in spray drying were prepared with three different ratios (1:1, 2:1 and 3:1). The product of co-processing were evaluated for morphology, moisture content, viscosity, angle of repose, flow rate of granules, bulk density, tapped density and Carr's index. Results showed that eo-process excipient of arrowroot starch-chitosan have spherical in shape, moisture content in the range of 4.70-5.10% w/w, viscosity in the range of •1.77-2.17 mPas, angle of repose was found to be < 38°, fiow rate of granules in the range of 1.5 - 4 g/s, bulk density in the range of 0.47-0.59 g/mL, tapped density in the range of 0.59-0.79 g/mL and Carr's index in the range of 19.03-25.08%.

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia;21(3)2010173-179

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2010

Collation

6p.

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

plants, medicinal

Specific Detail Info

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