Optimasi Formula Tablet Lepas Lambat Kaptopril Menggunakan Metode Desain Faktorial (Optimization of Formula Sustained Releaase Caotropril Tablet Using Factorial Design Method) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Optimasi Formula Tablet Lepas Lambat Kaptopril Menggunakan Metode Desain Faktorial (Optimization of Formula Sustained Releaase Caotropril Tablet Using Factorial Design Method)

Melinda Pratiwi - Personal Name; Lannie Hadisoewigyo - Personal Name;

Captopril Is one of the most frequently used medicine In the treatment of hypertension with repeatedly used frequency in a day. Therefore captopril should be formulated in the form of sustained release and find the optimum formula. The purpose of this study was to determine the Influence of both factors and their interactions, which are the ratio of polymer HPMC K4M - xanthan gum factor at the level of 1: 1 and 4: 1 and the concentration of tartaric acid at levels of 0% and 5% on physical properties of tablets, drug release, floating lag time. Furthermore, find the optimum formula that meets the requirements and produce tablets with drug release pattern according to zero order kinetics. Based on Design Expert optimization program was obtained the optimum formula using a combination of polymer HPMC K4M - xanthan gum ratio 3.75:1 and concentration of of tartaric acid 4.5% would be result the hardness respons 12.02 Kp the friability 0.47%, the floating lag time 0.32 minutes, and the rate of dissolution 0.05 mg/min. The results show that combination of factors polymer HPMC K4M ~ xanthan gum ratio can increase the tablet hardness, lower tablet friability, accelerate the floating lag time, and increase the rate of dissolution. Tartaric acid can decrease the tablet hardness, Increase the friability, accelerate the floating lag time, and Increase the rat of dissolution. Interaction of both can reduce the tablet hardness, increase the tablet, slow floating lag time, and increase the rate of disssolution.

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Location name is not set Majalah Farmasi Indonesia;21(4):285-295

A0001165

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Series Title: -
Call Number: Majalah Farmasi Indonesia;21(4)2010:285-295
Publisher: Yogyakarta : Fakultas Farmasi UGM,., 2010
Collation: 6p.
Language
ISBN/ISSN: 0126-1037
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): CAPTOVIL
Specific Detail Info: -
Statement of Responsibility: -

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