Text

Uji Aktivitas Senyawa Antiplasmodium dari Fungi Endofit Tanaman Artemisia Annua L. (Testing of Antiplasmodium Activity Substance From Endophytic Fungus of Artemisia Annaua L.)

---

Malaria is a life-threatening disease caused by Plasmodium parasites. The rapid spread of malaria-quinoline resistance enforce to find of new antlmalaria drug. Artemisia annua L having artemlslnln as secondary metabolltes, has been used as antlmalarla agent for long time. One of source of bioactive compound Is endophytic fungus. This fungus can produce similar bioactive compound to host plant. The thin layer chromatography result showed that endophytic fungus from A.annua had similar chromatogram profile with artemlsinin. This metabolite was not secreted in the fermentation medium" but was kept In the fungus mycelium. The result of the haem polymerization inhibitory activity assay showed that this secondary metabolites lnhtblted the haem polymerization. Ethyl acetate extract of fungus A had le,o value 0.824 % 2.89 ~M to Inhibit the haem polymerization; fungus E was 0.:861% 2.43 ~M; and fungus F was 1.394 % 3.73 ~M.

---

Availability

Detail Information

Series Title

-

Call Number

Majalah Farmasi Indonesia;21(4)2010:243-248

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2010

Collation

5p.

Language

ISBN/ISSN

0126-1037

Classification

-

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

antimalarials
PLANTS, MEDICINAL-CONGRESSES

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment