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Sintesis, Uji Aktivitas Analgesik dan Anti-Inflamasi Senyawa Benzolltiourea Tersubstitusi (Synthesis, Analgesic and Anti-inflamatory Activity or Substituted Benzoylthloureas)

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Three compounds (i.e. benzoylthiourea, 4-nitrobenzoylthiourea, and 4- chlorobenzoylthiourea) have been synthesized from ammonium thiocyanate, substituted benzoyl chlorides, and ammonia as starting materials. The structures of sythesized compounds were confirmed by means of ultra-violet, infrared, magnetic resonance, and mass spectroscopv. All compounds were evaluated for their analgesic and anti-inflamatory activities by tail-flick technique and
.• carragenan-induced paw oedema test respectively. Substitution of p-N02 and p-CI group to benzoylthiourea increased the analgesic and anti-inflamatory activities ... The two compounds, 4-nitrobenzoylthiourea and 4-chloro¬benzoylthiourea, were significantly more potent as analgesic but their anti¬inflamatory actvity was weaker than Na-diclofenac.

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia;21(1)2010:68-76

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2010

Collation

8p.

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

anti-inflammatory agents
ANALGENCIES

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