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Cloning and Molecular Analysis of HCVP7 Complete Coding Sequerence

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The hepatitis C virus (HCV) p7 protein is known essentialfor virus infection and replication. It exhibits ion¬channel tWtivity reported to be specifically blocked by various compounds, making it an attractive drug target. However, at present only little is known about the underlying molecular mechanisms of HCV p7. To predict and more understanding the molecular pattern ofHCV p7 we cloned the p7 gene ofHCVisolated in Central of lavalndonesia. The sequence results were then aligned with a/l ofHCV 1 a p7 complete coding sequences reported in GenBank. In total, 591 sequences were retrieved and aligned by ClustalW We revealed the nucleotide and amino acid sequence consensus of HCV p7 gene. Overall, only aa 5, 12, 30, 34, 42, 48, 52, 58, and 63 were not have any variation. Amino acid variations may have relevant changes of physicochemical properties so that influence the replication efficiency, therefore, the amino acid variations found in the present report need further study.

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Series Title

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Call Number

Biomedika;2(1)2010:17-20

Publisher

Surakarta : FK. Universitas Muhammadiyah Surakarta., 2010

Collation

3p,

Language

English

ISBN/ISSN

2085-8345

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

CLONING, MOLECULAR
HEPATITIS C ANTIBODES

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