Analisis Molekuler Gen Polymerase Basic 2 (PB 2) Virus Avian Influenza H5N1 yang diisolasi dari Unggas Asal Purworejo, Jawa Tengah dan Bantul, Yogyakarta | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

Search by :

ALL Author Subject ISBN/ISSN Advanced Search

Last search:

Text

Analisis Molekuler Gen Polymerase Basic 2 (PB 2) Virus Avian Influenza H5N1 yang diisolasi dari Unggas Asal Purworejo, Jawa Tengah dan Bantul, Yogyakarta

Riandini Aisyah - Personal Name; Tri Wibawa - Personal Name; Widya Asmara - Personal Name;

Polymerase Basic 2 (PB2) is the longest segment of Avianlnjluenza Virus (AIV) genome. has been known to play a role in cleavage and capping a/RNA, related with replication and transcription into 8 segments of virus genome. This study was aimed to find out the existence of amino acid change in positions 627 and 667 that Glutamate mutation into Lysine in position 627 PB2, determines the high pathogen and mutation in amino acid 667 into Lysine has been known as causingfavorable virus to replicate, homological level and its 3 dimension of protein structure. The analysis was carried out by comparing a certain part of the sequence of nucleotide of PH2 protein of two test isolate with other H5NI virus from avian and human comingfrom Asia. Europe. and Africa within 1996 - 2007 selectedfrom genebank. The result of the study showed that amino acid in position of 627 and 667 in th two test isolate had not mutated into Lysine. Phylogenetic analysis had also been carried out by comparing the two test isolate of62 isolates of avian influenza virus H5NI from human and other avian. The two test isolate still showed high homological level with isolatefrom Indonesia, especially Yogyakarta. Observation of 3 dimension structure, as a whole, the molecular characteristic of the two test isolate still showed the characteristic of amino acid residue generally in avian from Indonesia and several avian isolates from other countries

Availability

Location name is not set Biomedika;2(1):6-16

A0001120

Available

Detail Information

Series Title: -
Call Number: Biomedika;2(1)2010:6-16
Publisher: Surakarta : FK. Universitas Muhammadiyah Surakarta., 2010
Collation: 10p.
Language
ISBN/ISSN: 2085-8345
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): BIRDS
INFLUENSA IN BIRDS
INFLUENSA A VIRUS, H5N1 SUBTYPE
Specific Detail Info: -
Statement of Responsibility: -

Other version/related

No other version available

File Attachment

No Data

Comments

You must be logged in to post a comment