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Evaluasi of Prostate Basal Cell By Cytokeratin 903 Staining in Prostatic Adenocarcinoma Gleason Score 6

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To evaluation the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. During research period, we collceted 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prstate needle biopsy.Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on parafin block specimens analyzed on experienced pathologist. Positive results sugest a benign lesion. Mean age is 70±6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. There specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0.03). 15% cases of prostatic cancer Gleason score 6 still shoed basal cell existence. Immunohistochemical staining of basal cell should be concidered in suspicious cases of prostatic cancer

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Series Title

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Call Number

Jurnal Urology Indonesia;17(1)2010:17-19

Publisher

Surabaya : Ikatan Ahli Urologi Indonesia., 2010

Collation

2p.

Language

English

ISBN/ISSN

0853-4438

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Edition

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Subject(s)

PROSTATE
KERATINS
ADERNOCARCINOMA

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