Intratesticular Injection of 20% Hypertonic Sodium Chloride AS A Novel Castration Method; A Preclinical Study | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Intratesticular Injection of 20% Hypertonic Sodium Chloride AS A Novel Castration Method; A Preclinical Study

Marta Hendry - Personal Name; Endang Joewarini - Personal Name; Basuki B. Purnomo - Personal Name; Sunaryo Hardjowijoto - Personal Name; Dewa Ketut Meles Widodo Jp - Personal Name;

enefit of retaining both testes. To Demostrate that intratesicular injection of 20% hypertonic sodium chloride can result in permanent castration and to evaluate serum changes in sodium chloride levels. A total of 40 Wistar rats were divided into 4 groups, consisting of bilateral orchidectomy (n=10) and 2 group receving intratesticular injections of 20% sodium (n=10 in each group). Serum testosterone was measure on day 0. Day 1, day 15 and day 30. Serum sodium chloride was assessed before injection at 1 hour and 24 hours after injection. All testicles were harvested for histological examination. One way ANOVA and student t-test were used for statistical analysis. Serum testosterone decreased to castrate levels in the archidectomy and injected groups with no significant difference (p>0.05). Significant rise in serum sodium chloride was found 1 hour post injection (p≤0.05) but after 1 day it decreased significantly (p≤0.05). There was no significant difference in histopathological findings between the 2 injected groups after day 15 and 30(p>0.05). Twenty percent hypertonic chloride injection has te same permanent castration effect with bilateral orchidectomy in rats. The serum sodium chloride injection has the same permanent castration effect with bilateral orchidectomy in rats. The serum sodium chloride changes did not reach the level for rats. Therefore this treatment has a promising potential as a novel and cost-effective castration method with the additional b

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Location name is not set Jurnal Urologi Indonesia;17(1);1-8

A0001081

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Series Title: -
Call Number: Jurnal Urologi Indonesia;17(1)2010;1-8
Publisher: Surabaya : Ikatan Ahli Urologi Indonesia., 2010
Collation: 7p.
Language: English
ISBN/ISSN: 0853-4438
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Edition: -
Subject(s): infections
sodium chloride
COSTRATION
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Statement of Responsibility: -

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