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Peran alpa-Tocopherol sebagai Antitoksidan dan Prooksidan di Dalam Sel Manusia

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Abstract. a-tocopherol in in viva has the strangest antiaxidant activity amang ather farms of tocopherols, such as /3, }, and b This is due to. its ability in transferring hydragen ian tofree radicals, sa thefree radicals are stable. During oxidation pracess, a-tocopherol generates radikal tacapheraxyl that is cansidered to [unction as prooxidant. One of stableform of a-tocopherol is a-tocopheral succinate. The current study utilized human cell (WIL2-NS) to investigate the prooxidant effect of a-tocopherol succinate. MTT assay was carried out to. determine toxicity effect or praoxidant of a-tocopherol succinate. The safe doses of a-tocopherol succinate (antioxidant effect) for J hour exposure on human cell (WIL2-NS) are up to 25 j..lM, while for 24 hours exposure is 2.5 pM This study reveals that a-tocopherol succinate is potential antioxidant, however an certain doses a-tocopherol succinate will have detrimental effect on human cells (praoxidant effect).

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Detail Information

Series Title

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Call Number

Jurnal Skala Husada;7(2)2010:180-183

Publisher

Denpasar : Poltekes Denpasar., 2010

Collation

3p,

Language

ISBN/ISSN

1693-931X

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

antioxidants
CELLS
TOCOPHEROLS

Specific Detail Info

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