Aktivitas Antimalaria dan Skrining Metabolit Sekunder KayuBatang dan Kulit Akar Artocarpus Camansi Blanco (Maraceae) (Antimalaria Activity and Phytochemical Screening of Secondary Metabolites from Hearwood and Root Bark of Artocarpus Camansi Blanco (Moraceae) | Perpustakaan dan Galeri Kebijakan Kesehatan

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Aktivitas Antimalaria dan Skrining Metabolit Sekunder KayuBatang dan Kulit Akar Artocarpus Camansi Blanco (Maraceae) (Antimalaria Activity and Phytochemical Screening of Secondary Metabolites from Hearwood and Root Bark of Artocarpus Camansi Blanco (Moraceae)

Liefman Hakim - Nama Orang; Eka Junaedi - Nama Orang; Baiq Fara Dwi Rani Sofia - Nama Orang; Yunita Arian Sani Anwar - Nama Orang;

Abstract: Malarial parasite, Plasmodium, has been reported resistant to commonly used antimalarial drugs, such as chloroquin. Plants of Artocarpus genus are known to have high content of flavonoids. One of interesting bioactivitics of Artocarpus flavonoids is their antimalarial activity. This research is to investigate the potency of secondary mctabolites in the heartwood and root bark of Artocarpus camansi Blanco as an antimalarial agent. Antimalarial activity from methanol extract of heartwood and roots bark of A. camansi were tested in vitro to Plasmodium [alciparum 3D7 (strain sensitive to chloroquin) and W2 (strain resistant to chloroquin). The extracts were also phytochemically screened for compounds. The result showed that the methanol extract of heartwood and root bark of A. camansi Blanco inhibited the growth of Piasmodiumfatciparum 3D7 strain with IC" values of 1.84 ug/ml, and 32.13 IJ-g/mL, respectively; while similar antimalarial activity test to Plasmodium falciparum W2 strain showed IC50 values of 8.11 ug/rnl, and 17.10 IJ-g/mL, respectively. Phytochemical screening indicated that the heartwood and root bark of A. camansi Blanco contain flavonoids, terpenoids, and tannin; while coumarin and saponins arc present only in the root bark of A. camansi Blanco.

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Belum memasukkan lokasi Jurnal Ilmu Kefarmasian Indonesia; 8(2):131-135

A0001037

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Informasi Detail

Judul Seri: -
No. Panggil: Jurnal Ilmu Kefarmasian Indonesia; 8(2)2010:131-13
Penerbit: Jakarta : Fakultas Farmasi Universitas Pancasila., 2010
Deskripsi Fisik: 4p.
Bahasa
ISBN/ISSN: 1693-1831
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: antimalarials
ARTOCARPUS
PLASMADIUM FALCIPARUM
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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