Aktivitas Antimalaria dan Skrining Metabolit Sekunder KayuBatang dan Kulit Akar Artocarpus Camansi Blanco (Maraceae) (Antimalaria Activity and Phytochemical Screening of Secondary Metabolites from Hearwood and Root Bark of Artocarpus Camansi Blanco (Moraceae) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

Search by :

ALL Author Subject ISBN/ISSN Advanced Search

Last search:

Text

Aktivitas Antimalaria dan Skrining Metabolit Sekunder KayuBatang dan Kulit Akar Artocarpus Camansi Blanco (Maraceae) (Antimalaria Activity and Phytochemical Screening of Secondary Metabolites from Hearwood and Root Bark of Artocarpus Camansi Blanco (Moraceae)

Liefman Hakim - Personal Name; Eka Junaedi - Personal Name; Baiq Fara Dwi Rani Sofia - Personal Name; Yunita Arian Sani Anwar - Personal Name;

Abstract: Malarial parasite, Plasmodium, has been reported resistant to commonly used antimalarial drugs, such as chloroquin. Plants of Artocarpus genus are known to have high content of flavonoids. One of interesting bioactivitics of Artocarpus flavonoids is their antimalarial activity. This research is to investigate the potency of secondary mctabolites in the heartwood and root bark of Artocarpus camansi Blanco as an antimalarial agent. Antimalarial activity from methanol extract of heartwood and roots bark of A. camansi were tested in vitro to Plasmodium [alciparum 3D7 (strain sensitive to chloroquin) and W2 (strain resistant to chloroquin). The extracts were also phytochemically screened for compounds. The result showed that the methanol extract of heartwood and root bark of A. camansi Blanco inhibited the growth of Piasmodiumfatciparum 3D7 strain with IC" values of 1.84 ug/ml, and 32.13 IJ-g/mL, respectively; while similar antimalarial activity test to Plasmodium falciparum W2 strain showed IC50 values of 8.11 ug/rnl, and 17.10 IJ-g/mL, respectively. Phytochemical screening indicated that the heartwood and root bark of A. camansi Blanco contain flavonoids, terpenoids, and tannin; while coumarin and saponins arc present only in the root bark of A. camansi Blanco.

Availability

Location name is not set Jurnal Ilmu Kefarmasian Indonesia; 8(2):131-135

A0001037

Available

Detail Information

Series Title: -
Call Number: Jurnal Ilmu Kefarmasian Indonesia; 8(2)2010:131-13
Publisher: Jakarta : Fakultas Farmasi Universitas Pancasila., 2010
Collation: 4p.
Language
ISBN/ISSN: 1693-1831
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): antimalarials
ARTOCARPUS
PLASMADIUM FALCIPARUM
Specific Detail Info: -
Statement of Responsibility: -

Other version/related

No other version available

File Attachment

No Data

Comments

You must be logged in to post a comment