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Uji Aktivitas Sitotoksik dan Antioksidan Ekstrak Daun Keladi Tikus (Typhonium divaricatum (L) Deene) (Cytototoxicity and Antioxidant Activity Tests on Typhonium divaricatum (L) Decne Leaves)

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Abstract: Cytotoxic and antioxidant activities of Typhonium divaricatnrn (L) Decne leaves extract have
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been explored. Preliminary phytochemical screening on the extract were carried out for the compound's
profile. Biological activity was measured by using Brine Shrimp Lethality Test (BSLT), while cytotoxic activity was conducted on breast cancer cell line T-47D using MTT method. Antioxidant activity was measured by using DPPH free radical scavenging method. The results of phytochemical screening showed that the methanol extract contained flavonoid, saponin and stcroidltriterpenoid compounds, meanwhile the n-hexane extract contained steroid/triterpenoid compounds only. The highest biological activity was found in methanol extract (LCso == 32.9 ppm), The highest cytotoxic activity was shown by n-hexane extract (IC,o ~ 32.50 ppm). The highest antioxidant activity using vitamin C as positive control was found in methanol extract (lC,o ~ 56.63 ppm). The preliminary results indicated that Typhonium divaricatum (L) Decne leaves is potential for anticancer and free radical scavenger .
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Detail Information

Series Title

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Call Number

Jurnal Ilmu Kefarmasian Indonesia; 8(2)2010:118-12

Publisher

Jakarta : Fakultas Farmasi Universitas Pancasila., 2010

Collation

6p.

Language

ISBN/ISSN

1693-1831

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

CYTOTOXINS
ANTIOCIDANTS
PLANT EXTTROCTS

Specific Detail Info

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Statement of Responsibility

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