Formulasi Tablet Hisap Ekstrak Teh Hijau (Camelia sinensis L. Kuntz) dengan Penambah Vitamin C atau Ekstrak Biji Anggur (Vitis vinifera L.) dan Uji Aktivitas Antioksidannya (Formulation of Lozenges Containing Green Teh Extract (Camellia sinensis L. Kuntz) with Addition of Vitamin C or Grape Seed Extract (Vitis vinifera L.) and Their Antioxidant Activities) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Formulasi Tablet Hisap Ekstrak Teh Hijau (Camelia sinensis L. Kuntz) dengan Penambah Vitamin C atau Ekstrak Biji Anggur (Vitis vinifera L.) dan Uji Aktivitas Antioksidannya (Formulation of Lozenges Containing Green Teh Extract (Camellia sinensis L. Kuntz) with Addition of Vitamin C or Grape Seed Extract (Vitis vinifera L.) and Their Antioxidant Activities)

Swasono R. Tamat - Personal Name; Leonardus B.S. Kardono - Personal Name; Dewita Agus - Personal Name;

Abstract: Formulation of lozenges containing: A) green tea extract; B) green tea extract with sodium ascorbate; and C) green tea extract with grape seed extract have been carried out. Antioxidant activities were compared to the activity of raw active materials. Lozenges were tested for physical characteristics, hedonic values, dissolution rate, and stability during storage. Physical tests indicated that the lozenges comply with the Farmakope Indonesia IV requirements. Determination ofIC5o antioxidant activity using DPPH free radical scavenger showed that lC,o of formula A, B, and C were 844.04 ug/rnl., 221.80 )lg/ mL, and C 57.4 ug/rnl., respectively. Meanwhile, IC50 value of green tea extract, sodium ascorbate, and grape seed extract were 4.29 ug/rnl., 12.95 ug/ml., and 1.96 ug/ml., respectively. Accelerated stability test were carried out based on the EGCG concentration observed by using HPLC and then calculated by Arrhenius equation showed that the shelf life of lozenges of formula A, B, and C were 2.11 years; 1.87 years; and 2.73 years, respectively. The result showed that the lozenge containing green tea extract and grape seed extract (formula C) is the best formula based on FI LV requirements, antioxidant activity and lozenges stability.

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Series Title: -
Call Number: Jurnal Ilmu Kefarmasian Indonesia; 8(2)2010:108-11
Publisher: Jakarta : Fakultas Farmasi Universitas Pancasila., 2010
Collation: 9p.
Language
ISBN/ISSN: 1693-1831
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): antioxidants
ascorbic acid
tablets, enteric-coated
PLANTS EXTRACTS
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Statement of Responsibility: -

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