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Comparation of Lung Function Values in Controlled and Uncontrolled Diabetes Mellitus Patient in Persahabatan Hospital Jakarta

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Introduction. Diabetes mellitus (DM) is a metabolic disorder. DM affects various organs of human body. Hyperglycaemic state can reduce lung function by decreasing elastin proteins and lung surfactans. Moreover, it can cause diffusion perfusion disorders. Haemoglobin A 1 c (HbA,ol describes previous 3 months of patient's glycaemic state. HbA" is a gold standard to determine controlled and uncontrolled DM patients. In a recent study, diabetic patients with HbA,c below 6.5% have better lung function than those abov'). 6.5%.
Methods. We conducted a study to analyze 60 DM patients who came to endocrinology clinic in Persahabatan Hospital Jakarta Indonesia from May-August 2008. We divided DM type 2 patients in two groups (controlled and uncontrolled). Patient's interview, physical examination and chest X-rays were performed to excluded lung diseases. Fasting and post prandial blood glucose, body mass index (BMI) and lung function test (forced vital capacity and forced expiratory volume in 1 second) were measured.
Results. We studied 60 DM patient of which 40% were male (24 of 60) and 60% were female (36 of 60). The majority of patients was 50 to 65 y.o and the mean age was 56.9 ± 7.35 y.o. We found that 32 patients had HbA,c above 6.5% and 28 patients below 6.5%. The uncontrolled patients group showed forced vital capacity (FVC) 82.5% of predicted compared to 90.6% in controlled patient (P=0.001) and forced expiratory volume in 1 second (FEV,) of controlled patient was 88.6% of predicted compared to 87.6% of predicted in uncontrolled patient (P=0.728).
Conclusions. Decreasing of FVC in uncontrolled diabetes mellitus patients is more significant than in controlled DM patients. However, decreased FEV, between the two groups was not significantly different. This study showed a correlation between decreased FVC and uncontrolled DM. Uncontrolled DM is found to have a more severe lung restriction than controlled DM.
Keywords: Diabetes mellitus, HbA,c' FVC, FEV,

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Jurnal Respirologi Indonesia31(3)2010:134-145

Publisher

Jakarta : Perhimpunan Dokter Paru Indonesia., 2010

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11p.

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0853-7704

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Subject(s)

diabetes mellitus, insulin-dependent
lung

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