Efek Anti Inflamasi Ekstrak Air Biji Kedelai Kuning (Glycine max) terhadap Udem pada Tikus Putih (Rattus norvegicus) Jantan yang Diinduksi Karagenin 1% | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Efek Anti Inflamasi Ekstrak Air Biji Kedelai Kuning (Glycine max) terhadap Udem pada Tikus Putih (Rattus norvegicus) Jantan yang Diinduksi Karagenin 1%

Novya Kusumaningrum - Personal Name; Isnatin Miladiyah - Personal Name;

Inflammation is a physiologic process of body if there is an injury mechanism, but if it's happened excessively can threaten body. Anti-inflammation drugs were needed to control the dangerous effects. Because of synthetic anti-inflammation drugs are known have many harmful side effects, the traditional ones need to develop as altemative, one of them is soybean that guessed have the quality as an anti-inflammation. The objective of this study is to investigate the anti-inflammation effect of water extract of soybean's seed in white male rat's 1% carrageenan-induced paw edema. This study is a true experimental. one that using 25 white male rats with 2-3 months of age and 200-250 grams of weight which divided into 5 groups, those are aquadest group, Dexamethasone group with 0,013 mg/200 g of rat's weight in dose, and three concentration levels of water extract of soybean's seed: 2,5%, 10%, and 40% orally. Thirty minutes after exposured by each group treatment, all of rats were injected with 0,1 mL of 1 % carrageenan into left paw subplantarly. Paw edema volume was measured with plethysmometer every 30 minutes along 6 hours. Anti-inflammation capacity was measured by the comparison of AUC value between control and intervention groups. Statistic test was using SPSS with One Way ANOVA method that continued by post-Hoc test. The result shown that water extract of soybean's seed can reduce the rat's paw edema volume, but less effective than Dexamethasone (positive control). There is no adequate evidence to show that wafer extract of soybean's seed was effective as an anti-inflammation compared to Dexamethasone yet.

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Location name is not set Jurnal Kedokteran dan Kesehatan Indonesia:2(4):46-

A0000874

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Series Title: -
Call Number: Jurnal Kedokteran dan Kesehatan Indonesia:2(4)2010
Publisher: Yogyakarta : FK. Universitas Islam Indonesia., 2010
Collation: 10p.
Language
ISBN/ISSN: 2085-4145
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): anti-inflammatory agents
soybeans
rats
CARROGEENAN
Specific Detail Info: -
Statement of Responsibility: -

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