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Incretin-Based Therapies for Type 2 Diabetes in Asian Patients: Analysis of Clinical Trials

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Aim To review the efficacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population.
Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populaticns. Data pertinent to the efficacy and safety of GLP-l mimetics and DPP-4 inhibitors were extracted and used.
Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbAlc at higher extent (lip to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and ~1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profile.
Conclusion The efficacy of in cretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (Med J. lndones 2010; 19: 205-12)

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Series Title

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Call Number

Medical Journal of Indonesia;19(3)2010:205-212

Publisher

Jakarta : Faculty of Medicine University of Indonesia., 2010

Collation

7p.

Language

English

ISBN/ISSN

0853-1773

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Edition

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Subject(s)

clinical trials
THERAPY
IABETES MELLITUS, TYPE2

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