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The Association of Plasminogen Activator Inhibitor-I Level with Ischemic Stroke (Preliminary Study)

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Aim Recently, increased plasminogen activator inhibitor-I (PAl-I) has been known a risk factor for ischemic heart disease. However, the association of increased PAl-I level with ischemic stroke remains unclear. The aim of this study was to analyze the association of PAl-I level with ischemic stroke.
Methods By case control design we involved 38 ischemic stroke and 38 risky-matched control subjects who fulfilled the criteria. The PAl-I level was determined by ELlSA method using Asserachrom PAl-I from Stago.
Results High PAl-I level was found more frequent in ischemic stroke subjects than in control subjects (21.1% vs. 7.9 % with QR 3.1; 95 % CID. 757 - 12.790). The analysis of all studied subjects showed that there was a weak negative correlation between PAI-l level and age (r = -0.4; P = 0.000). High PAI-l level was found more frequent in younger (40 - 58 years old) than in the older subjects (60 - 84 years old) (20% vs. 9.8 %) (FO.004).
Cencfusion The result of this preliminary study suggested an association between PAI-l level and ischemic stroke in younger age. Further study with larger subjects is recommended to confirm this association. (Med J tndones 2009; 19:158 -63)

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Detail Information

Series Title

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Call Number

Medical Journal of Indonesia;19(3)2010:158-163

Publisher

Jakarta : Faculty of Medicine University of Indonesia., 2010

Collation

5p.

Language

English

ISBN/ISSN

0853-1773

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Edition

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Subject(s)

ischemia
CEREBROVASCULAR ACCIDENT
PLASMINOGEN ACTIVATES INHIBITOR i

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