Demographic Characteristics, Risk Factors and Immunocytochemitry of p16INK4a, Ki-67, MCM5, and Survivin as Predictors for the Progress of Cervical Precancer Lesion | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Demographic Characteristics, Risk Factors and Immunocytochemitry of p16INK4a, Ki-67, MCM5, and Survivin as Predictors for the Progress of Cervical Precancer Lesion

Junita Indarti - Personal Name; Alida Harahap - Personal Name; Bethy Suryawati - Personal Name; Nuryati C Siregar - Personal Name; Bambang Sutrisno - Personal Name; Mohammad F. Aziz - Personal Name;

Aim To identify the predictive factors and biomarkers in the progression of cervical precancer lesion or Cervical intraepithelial Neoplasia (CIN).
Methods The study was conducted from August 2007 to September 2008. Design of the study was case-control with stratifications of test dose response. The cases were patients with CIN. Control patients were non CIN patients. Bivariate analysis followed by multivariate analysis was conducted.
Results There were 130 patients, consisting of124 CIN patients divided into CIN 1, CIN 2 and CIN 3, with the following numbers of patients: 30, 41, and 33, respectively and 26 patients without CIN (non CIN). Bivariate analysis showed that age < 41 years, education > 13 years, sexual partner z 2, first sexual relationship at age < 22 years, smoking, the presence of sexuallly transmitted infections, positive HPV DNA, high P 16'NK4a, Ki-67, MCM5 and Survivin expression constituted independent variables for the occurrence of CIN with P value of < 0.05. However, on multivariate analysis, independent variables that emerged were age, education z 13 years, sexual partner> 2 persons, positive HPV DNA, and over expression ofp 16INK4a, Ki-67 and Survivin that showed a P value of < 0.005.
Conclusion Younger ages, education age > 13 years, sexual partner > 2 persons, positive HPV DNA, high p161NK4a, Ki-67 and Survivin expression constituted the risk factors for the occurrence ofthe progress of CIN, and was used in the equation to predict the progress of cervical precancer lesion. (Med J lndones 2010; 19:147-53)

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Location name is not set Medical Journal Indonesia;19(3):147-153

A0000833

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Series Title: -
Call Number: Medical Journal Indonesia;19(3)2010:147-153
Publisher: Jakarta : Faculty of publik health, mahidol university., 2010
Collation: 6p.
Language: English
ISBN/ISSN: 0853-1773
Classification: -
Content Type: -
Media Type: -
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Edition: -
Subject(s): RISKFACTORS
IMMUNOHISTCHEMISTRY
CERVICAL INTROEPITHALIAL NEOPLASIA
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Statement of Responsibility: -

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