Demographic Characteristics, Risk Factors and Immunocytochemitry of p16INK4a, Ki-67, MCM5, and Survivin as Predictors for the Progress of Cervical Precancer Lesion | Perpustakaan dan Galeri Kebijakan Kesehatan

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Demographic Characteristics, Risk Factors and Immunocytochemitry of p16INK4a, Ki-67, MCM5, and Survivin as Predictors for the Progress of Cervical Precancer Lesion

Junita Indarti - Nama Orang; Alida Harahap - Nama Orang; Bethy Suryawati - Nama Orang; Nuryati C Siregar - Nama Orang; Bambang Sutrisno - Nama Orang; Mohammad F. Aziz - Nama Orang;

Aim To identify the predictive factors and biomarkers in the progression of cervical precancer lesion or Cervical intraepithelial Neoplasia (CIN).
Methods The study was conducted from August 2007 to September 2008. Design of the study was case-control with stratifications of test dose response. The cases were patients with CIN. Control patients were non CIN patients. Bivariate analysis followed by multivariate analysis was conducted.
Results There were 130 patients, consisting of124 CIN patients divided into CIN 1, CIN 2 and CIN 3, with the following numbers of patients: 30, 41, and 33, respectively and 26 patients without CIN (non CIN). Bivariate analysis showed that age < 41 years, education > 13 years, sexual partner z 2, first sexual relationship at age < 22 years, smoking, the presence of sexuallly transmitted infections, positive HPV DNA, high P 16'NK4a, Ki-67, MCM5 and Survivin expression constituted independent variables for the occurrence of CIN with P value of < 0.05. However, on multivariate analysis, independent variables that emerged were age, education z 13 years, sexual partner> 2 persons, positive HPV DNA, and over expression ofp 16INK4a, Ki-67 and Survivin that showed a P value of < 0.005.
Conclusion Younger ages, education age > 13 years, sexual partner > 2 persons, positive HPV DNA, high p161NK4a, Ki-67 and Survivin expression constituted the risk factors for the occurrence ofthe progress of CIN, and was used in the equation to predict the progress of cervical precancer lesion. (Med J lndones 2010; 19:147-53)

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Belum memasukkan lokasi Medical Journal Indonesia;19(3):147-153

A0000833

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Judul Seri: -
No. Panggil: Medical Journal Indonesia;19(3)2010:147-153
Penerbit: Jakarta : Faculty of publik health, mahidol university., 2010
Deskripsi Fisik: 6p.
Bahasa: English
ISBN/ISSN: 0853-1773
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: RISKFACTORS
IMMUNOHISTCHEMISTRY
CERVICAL INTROEPITHALIAL NEOPLASIA
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