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Negative Impact of imflammation and Insulin Resistance on the biogenesis of HDL-c in Indonesia men With Metabolic Syndrome

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Aim To find out the relationship between inflammation and insulin resistance with impaired HDL biogenesis that cause low HDL-c concentration
Methods Using a cross-sectional design, this study involved 163 adult men, aged 25-60 years old with metabolic syndrome (IDF criteria, 2005), without liver and kidney dysfunction. This study was undertaken in Jakarta in the year 2007-2009. ~easured indicators were serum apclipoprotein A-I (apoA-I), prebeta-l HDL, cholesteryl ester transfer protein (CETP), HDL cholesterol (HDL-c), body weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), and triglyceride, The apoA-I/HDL-c ratios were taken as indicatorofHDL maturation, whereas CETP/HDL-c and CETPtrG ratios were indicated HDL catabolism. high-sensitivity CRP (hsCRP) and HOMA-lR were taken as indicator of inflammation and insulin resistance, respectively. Data were analyzed by using univariate, bivariate, and multivariate analysis.
Results Positive correlations were found between hsCRP and CETP (rs= 0.200, p= 0.042), and CETPIHDL-c ratios (rs= 0.188, p= 0.013). HOMA-IR positively correlated with apoA-I/HDL-c ratios (rs= 0.190, p= 0.016) and negatively correlated with the CETPrrG ratios (rs= -0,162, p= 0.04). Results of general linear model analysis showed that serum hsCRP concentration had the highest contribution to CETPIHDL-c ratios, apoA-I, dan CETP (p= 0.009; 0.016; 0.054, respectively).
Conclusions Inflammation and insulin resistance related to dysfunction of HDL biogenesis in men with metabolic ~ syndrome. The inflammation correlated with increased HDL catabolism, whereas the insulin resistance correlated with decreased HDL maturation and increased HDL catabolism. These may lead to low HDL-c concentration. lnf1ammation had higher contribution to HDL biogenesis (actors than insulin resistance. (Med J lndoncs 2010,. 19:36-45)

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Medical Journal Indonesia;19(1)2010:36-45

Penerbit

Jakarta : Facultyof Medicine University of Indonesia., 2010

Deskripsi Fisik

9p.

Bahasa

English

ISBN/ISSN

0853-1773

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

METABOLIC SYNDROME
INFLAMATION
INSULINRESISTANCE
HIGH -DENSITY LIPOPROTEINS, PRE-BETA

Info Detail Spesifik

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Pernyataan Tanggungjawab

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