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Androgen Receptor Levels During Progression of Prostate Cencer in the Transgenic Adebocarcinoma of Mouse Prostate Model

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Aim To construct tissue microarrays (TMAs) that consisted of prostate tumours from the transgenic adenocarcinoma of mouse prostate (TRAMP) mice and non-transgenic murine prostates and to assess androgen receptor (AR) levels during progression of prostate cancer in TRAMP mice by immunohistochemistry.
Methods Haematoxylin and eosin (H&E) sections from the ventral and dorso-lateral prostate lobes of non-transgenic, intact TRAMP and castrated TRAMP were used to demarcate regions of interest for TMAs construction. The samples on TMAs were used to evaluate AR expression using video image analysis (VIA).
Results AR was expressed during cancer progression, but AR levels were reduced or absent in late stage disease. Further¬more, when AR levels were compared in tumours from intact and castrate animals, a significant increase in AR levels was observed following androgen ablation.
Conclusion Similar to clinical prostate cancer, in the TRAMP model, prostate tumours evolve mechanisms to maintain AR expression and AR responsive gene pathways following castration to facilitate continued tumour growth. (Med J lndones 2010; 19:5-13)

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Detail Information

Series Title

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Call Number

Medical Journal Indonesia;19(1)2010:5-13

Publisher

Jakarta : Faculty of Medicine University of Indonesia., 2010

Collation

8p.

Language

English

ISBN/ISSN

0853-1773

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PROSTATIC NEOPLASME
RECEPTORS, ANDROGEN

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