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GYP 1A1 Polymorphism in Acne Vulgaris Patients in Makasar: Adescriptive study

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Cyp 1a1 Gene Polymorphism In Acne Vulgaris Patients In Makassar: A Descriptive Study
Acne vulgaris is a multifactorial disease caused by the presence of chronic inflammation in the pilosebaceous unit of the skin. Although it is considered to be an inherited disease, there are limited data supporting the involvement of genetic factor in its etiology. CYP 1A1 is by far the most active form and its natural metabolites are morphogenic for sebaceous gland. Forty two patients with acne vulgaris were included in the study. One microliter of blood sample were collected from each. Sequencing polymerase chain reaction (PCR-sequencing) assay was used for detection of the CYP 1 A 1 gene. The genomic collection observed with an explorative method and compared the genotype frequencies to its allele frequencies. The genotype distribution of this study was compared the genotype distribu-tion of our study to other previous studies. The frequency of GG genotype was 33,3%, GA genotype was 40,5% and AA genotype was 26,2%. There was a significant relationship in genotype distribution between our study and the previous studies in German. There is a significant correlation between CYP 1A1 gen e polymorphism and acne vulgaris.

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Detail Information

Series Title

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Call Number

Ebers Papyrus:16(1)2010: 29-35

Publisher

Jakarta : FK. Universitas Tarumanegara., 2010

Collation

6p.

Language

English

ISBN/ISSN

0854-8862

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

POLYMORPHISM, GENETIC
ACNE VULGARIS

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