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Efficacy of Nigella Sativa on Serum Free Testosterone and Metabolic Disturbance in Central Obsese Male

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To study the efficacy of Nigella sativa in central obese men on serum freetestosterone, body weight, waist circumference, blood sugar, lipid, uric acid, adiponectin, hs-CRP, and side effects in the treatment group compare to control. An experimental, clinical test, double blined with placebo control, pre-test and post-test design. Subjects are 30-45 years old, devided into the treatment and control groups, and evaluated weekly for 3 months. Data obtained were subjecttive complaints, body weight, waist circumference, and blood pressure, serum free testosterone, fasting blood sugar, triglyceride, HDL-Cholesterol, uric acid, creatinin, SGTO and SGPT, adiponectin, and hs-CRP. Data collected froMarch 2007 to June 2007 at Prof. Dr. RD Kondou General Hospital, Manado, North Sulawesi, Indonesia. Statistical analysiswas performed using descriptive for subjects characteristic and drug’s side effects, t independent compare between two parametric independent to compare between two parametric independent variable. Mann-Whitney U to compare between two non-parametric independent variables, and Wilcoxon Signed ranks test to compare between between two non-parametric dependent variables. In the treatment group, complaints related to central obesity disappear in first week, very significant reduction of body weight, waist circunference, and systolic blood pressure, insignificant reduction in serum free testosterone, diasttolic blood pressure reduction in serum free testesterone, diastolic blood pressure, fasting blood sugar, triglyceride and cholesterol-HDL, uric acids, hs-CRP, and signifcant increase of adiponetin. On comparison between both groups, we found a very significant reduction on body weight and wasit circumference, but the insignificant reduction on serum free testosterone, systolic and diastolic blodd pressure, and the unsignificant increase of adiponectin, meanwhile the reduction of serum free testosterone in the treatment group was smaller than the control group, than means Nigella sativa could inhibit the decreasing of serum free testerone. No side effects were detected in the treatment group. Although the other variables in the treatment group were not significantly different, we found them better than the control group, which can be a good sign for metabolic restoration in COM. It is suggested that larger dose and longer duration of NS comsumption will give better result

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Detail Information

Series Title

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Call Number

Acta Medica Indonesiana:42(3)2010:130-134

Publisher

Jakarta : Indonesia Society of Internal Medicine., 2010

Collation

4p.

Language

English

ISBN/ISSN

0125-9326

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

vacuum extraction, obstetrical
SERUM ANMYLOID a PROTEIN
NIGELLA SATIVA
TESTOTERONE

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