Metastatic Poorly Differentiated Adenocarcinoma of The Stenum Unsolved Diagnostically by Immunohistochemical Staining: A Cases Report | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Metastatic Poorly Differentiated Adenocarcinoma of The Stenum Unsolved Diagnostically by Immunohistochemical Staining: A Cases Report

Hanggoro Tri Rinonce - Personal Name; Soeripto - Personal Name; J Bras - Personal Name;

A 42 year-old male admitted to Dr. Sardjito Hospital, Yogyakarta because of a painful sternal mass that was becoming larger since 6 months before hospitalized. He was diagnosed as malignant thymoma based on microscopic examination of specimen obtained from FNAB. Histological examination from biopsy specimen showed a tumor, composed of epithelial cells and arranged in nests, solid, partly tubular and glandular structures considered thymic carcinoma with differential diagnosis a poorly differentiated adenocarcinoma. PAS staining was positive and PAS diastase was negative, considered that the cytoplasm contained glycogen. The tumor cells showed expression of poly keratin (CAM5.2, TTF1, and CD1 0). Neurogenic and neuroendocrine markers (5100, CD56, CD 57), mesothelial markers (calretinin, EMA), and mesenchymal markers (vimentin, CD68, desmin, 5MA) are negative. The impression was metastatic adenocarcinoma. In case of metastatic one could consider a metastasis of a lung adenocarcinoma or thyroid carcinoma (TTF1 +, but CD1 0 expression did not fit) and renal cell carcinoma (CD 1 0 +, but TTF1 did not fit). The final considered diagnosis was poorly differentiated adenocarcinoma, metastasis from the lung, thyroid, or kidney.
The aim of this presented article is to report a difficult case of metastatic poorly differentiated adenocarcinoma of the sternum in which immunohistochemical staining could not solve the morphological diagnostic problems, to emphasize the importance of clinical information and good morphologic evaluation to determine the diagnosis.

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Series Title: -
Call Number: Journal of the Medical Sciences:42(1)2010:52-57
Publisher: Yogyakarta : Faculty of Medicine Gadjah Mada Universiti., 2010
Collation: 5p.
Language: English
ISBN/ISSN: 0126-1312
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Edition: -
Subject(s): adenocarcinoma
NEOPLASM METOSTASIS
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