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The Frequency of non Tuberculosis Mycobacteria Among Isoniazid Resistant Mycobacterium Isolates and the Pattern of Resistance to Antituberculosis Drugs

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Non tuberculosis mycobacteria (NTM) could be the causative agents of various clinical infections, especially in immunocompromised individuals. However, frequency of this bacteria among Mycobacterium isolates is not ye known. Moraver, their pattern of resistance to antituberculosis drugs has not been reported. The aim of the study is to determine the frequency of NTM among isoniazid resistant Mycobacterium isolates and the pattern of resistance to antituberculosis drugs. The clinical isolates of isoniazid-resistant mycobacteria collected from several laboratories in Java were cultured on Lowenstein Jensen (LJ) medium and followed by drug sensitivity testing. Identification of NTM was based on standard microbiological test: colony morphology, duration of growth, acid fast staining, and biochemical test (niacin test and nitro benzoic acid medium test). All isolates were resistant to rifampicin, 81.20% were streptomycin resistant, and half of them were resistant to ethambutol. Pattern of resistance to the second line antituberculosis drugs (ciprofloxacin, kanamicin, and ofloxacinl was variable with the range of 37,5% to 62,5%. In conclusion, almost all NTM isolates were resistant to rifampicin and streptomycin, whereas more than half of isolates were resistant to the second line drugs (ciprofloxacin, kanamicin, and ofloxacin).

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Series Title

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Call Number

Journal of the Medical Sciences:42(1)2010:16-20

Publisher

Yogyakarta : Fakulty of Medicine Gadjah Mada University., 2010

Collation

4p.

Language

English

ISBN/ISSN

0123-1312

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Edition

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Subject(s)

CHOLECYSTECTOMY, LAPAROSCOPIC
TRANSAMINASES

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