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Plasma Iron, Zinc, and Copper Levels in Heart Diseases Patients in Dr. Sardjito Hospital Yogyakarta

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Heart disease is a major cause of death in both men and women in industrialized countries. In fact, many individuals, who develop heart disease, have normal cholesterol and blood pressure levels. It suggests that other risk factors may also play a role. Iron (Fe), zinc (Zn) and copper ICul may promote CHD by increasing lipid peroxidation and causing oxidant-induced damage in various organs. These minerals are essential as cofactors for functional enzymes in the body. The hypothesis that Fe and Cu depletion protects against ischemic heart disease has generated significant debate, but this hypothesis cannot be rejected until stronger evidence that high Fe stores increase the incidence of CHD or death from myocardial infarction is proven. This research was aimed to find out the levels of Fe, Cu. and Zn plasma as risk factors for heart disease patients, compared with those in hyperlipidemic patients and controls. In this study, we examined the Fe, Zn and Cu levels in plasma of CHD patients, hyperlipidemic patients, and healthy controls by atomic absorption spectrophotometer. Thirty five CHD patients, 31 hyperlipidemic patients, and 26 healthy controls. Age, body weight, body height, BM!, systolic and diastolic blood pressure of each group were not significantly different (p > 0.05). There were higher cholesterol and lower HDL-C levels in CHD patients compared with those in hyperlipidemic patients and controls. There were significantly higher triglyceridemia level in hyperlipidemic patients compared to those in CHD patients and controls. Iron level in CHD patients were not significantly different than those in hyperlipidemic patients and controls. Zinc level in CHD patients were not significantly different compared with those in controls, but in hyperlipidemic patients, they were significantly lower than those in CHD patients and controls. Copper level in CHD and hyperlipidemic patients were significantly lower than those in controls. In this research, it could be concluded that the decrease in Cu level might be one of the risk factors of CHD.
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Series Title

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Call Number

Jouurnal of Medical Sciences: 42(1)2010:4-9

Publisher

Yogyakarta : Fakulty of Medicine Gadjah Mada University., 2010

Collation

5p.

Language

English

ISBN/ISSN

0126-1312

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Subject(s)

heart diseases
iron
zinc oxide-eugenol cement

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