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Pengaruh Pemberian Ekstrak Buah Mahkota Dewa Dosis Bertingkat terhadap Proliferasi Limfosit Lien pada Mencit BALB/C.

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Mahkota dewa (phaleriapapuana) fruits consists of chemicals that able to increase lymphocytes proliferation. The objective of this study was to show the influence of Mahkota dewa’s fruits extract in spleen lymphocytes proliferation of BALB/C mice. An eperimental studywith the post-test only control group design was carried out on experiment animal BALB/C mice. An experimental study with the post-test only control group design was carried out on experiment animal BALB/C mice, consisted of 25 male which which devided into 5 groups. K was control group without treatment with mahkota dewa extract, whereas P1 was group treated with mahkota dewa extract 0,2 ml/day( ±35 lg extract). P2 was group given mahkota dewa extract 0,4 ml/day ( ±140lgextract), and P4 was group given mahkota dewa 1,5 ml/day (±280 lg extract). Lympgocytes from the spleen of all mice were isolated after 2 weeks treating. Lymphoblasts were counted in every 200 cells. There were significant differences in lymphoblasts count between K and P1 (p=0,0009), K and P2 (p=0,028), P1 and P2 (P=o,009), P1 and P3 (p=0,009), P1 and P4 (p=0,009). P2 and P3 (p=0,012), P2 and P4 (p=0,028). And there were no significant differences in lymphoblasts count between K and P3 (p=0,917), K and P4 (p=0,028). And there were no significant differences in lymphoblasts count between K and P3 (p=0,917), K and P4 (p=0,675), P3 and P4 (p=0,917). On the giving of mahkota dewa’s furts extract there were significant increase of lymphocyte proliferations on BALB/C mice on P1 and P2 groups. But there were not on P3 and P4 ones.

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Ketersediaan

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Judul Seri

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No. Panggil

Biomedika:1(2):33-36

Penerbit

Solo : FK Universitas Muhammadiyah Surakarta., 2009

Deskripsi Fisik

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Bahasa

ISBN/ISSN

2085-8345

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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