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Expression and Activation of NF-kB p65 Subunit of Mononuclear Cell at Steroid Resistance Nephrotic Syndrome in Childhood Patients.

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Resitance to steroid therapy is a poor prognosis sign for nephrotc syndrome, but the mechanism is still unclear. NF-kB has been reported to affect the glucocortiroid at the T cell through the transrepression in the glucocorticoid receptor. Until know, this study was still limated. The aim of this study was to show the difference expression and activation of NF-kB p65 subunit between childhood SRNS and SSNS patient. Cross sectional study was conducted during January 2009 to December 2009 in the Saiful Anwar General Hospital and Biomedic Laboratory Brawijaya University. Expression and activation of NF-kB p65 subunit were determine by immunochemistry staining by counting the amount of lymphocyte that express and activate NF-k8 p65 subunitamong 200 lymphocytes under ligh microsope with 1000 magnification. Result was analyzed by independent t test with 95% CI (p

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Jurnal Kedokteran Brawijaya:25(3):133-137

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Malang : FK Universitas Brawijaya., 2009

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0216-9347

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