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The Role of Msxl and Pax9 in Pathogenetic Mechanisms of Tooth Agenesis

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Tooth agenesis is one of the most common developmental anomalies, which one or a few teeth are absent because they have never formed, amy cause cosmetic or acclusal harm, while severe agenesis which are relativel rare relatively rare requre clinical attention to support and maintain the dental function. Molecular studies have demonstrated that tooth development is under strict genetic control. This article want to review the genetic regulating that are responsible for tooth ngenesis espectally the role of msxl and Pasy 9 in pathogenetic mechanisms of tooth agenesis. Tooth agenesis is a consequence of aqualitatively or quantitatively unpaired function of genetic networks, which regulate tooth development. Mutation in Maxl and Pas9 genes are domain containing trenascription factoe that plays an essential role in the development of normal dentition, heas been associated with selective toooth abenesis in humans and mice. Reduced amount of functional Msxl or pax9 protein in the tooth forming cells is able to cause sevre and selective tooth agenesis. There are differecces in the frequency of agenesis of specific teeth associated with the defects in Msxl and defects in pax9

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Series Title

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Call Number

Dental Journal: 42(3):141-146

Publisher

Surabaya : FKG Universitas Airlangga., 2009

Collation

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Language

English

ISBN/ISSN

1978-3728

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Edition

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Subject(s)

dental enamel

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