Text

Antioxidant Effect of Minocycline in Gingival Epithelium induced by Antinobacillus Actiomycetemcomitans Serotype B Toxin

---

Actinobacillus actinomycetemcoitans (Aa) serotype B has been associated with aggressive periodontitis. Gingival epitelial cel is expasitely sensitive to the toxin and may lead to the epithel protective barier disruption. Experimental models show that minocycline is not related to it’s disease. This study, examined antioxidant effects of menocycline to inhibit apoptisis of gingival epithelium induced crude toxin bacteria Aa serotype B in mice. Tthirty adult mice strain Swiss Webster (balb C) were divided randomly into thre groups: control group (group A), toxin group (group B) and toxin and minocycline group(group C). The mice were taken at 24 hours after application, and then the ticcue sections of gival epithelium were staines with tunnel assay and immunohistochemistry. Treatment with these toxin induced apoptosis of gingival epithelium and was associated with DNA fragmentation and reduced gluthation (GSH), Minocyline 100 nM significantly epithelium and was associated with DNA fragmentation and reduced gluthatione (GSH). Minocycline 100nM significantly increased GSH and reduced apoptosis (p

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

Dental Journal: 42(1):41-49

Penerbit

Surabaya : FKG Universitas Airlangga., 2009

Deskripsi Fisik

-

Bahasa

English

ISBN/ISSN

1978-3728

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

antioxidants
gingival diseases

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar