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Antioxidant Effect of Minocycline in Gingival Epithelium induced by Antinobacillus Actiomycetemcomitans Serotype B Toxin

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Actinobacillus actinomycetemcoitans (Aa) serotype B has been associated with aggressive periodontitis. Gingival epitelial cel is expasitely sensitive to the toxin and may lead to the epithel protective barier disruption. Experimental models show that minocycline is not related to it’s disease. This study, examined antioxidant effects of menocycline to inhibit apoptisis of gingival epithelium induced crude toxin bacteria Aa serotype B in mice. Tthirty adult mice strain Swiss Webster (balb C) were divided randomly into thre groups: control group (group A), toxin group (group B) and toxin and minocycline group(group C). The mice were taken at 24 hours after application, and then the ticcue sections of gival epithelium were staines with tunnel assay and immunohistochemistry. Treatment with these toxin induced apoptosis of gingival epithelium and was associated with DNA fragmentation and reduced gluthation (GSH), Minocyline 100 nM significantly epithelium and was associated with DNA fragmentation and reduced gluthatione (GSH). Minocycline 100nM significantly increased GSH and reduced apoptosis (p

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Series Title

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Call Number

Dental Journal: 42(1):41-49

Publisher

Surabaya : FKG Universitas Airlangga., 2009

Collation

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Language

English

ISBN/ISSN

1978-3728

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

antioxidants
gingival diseases

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