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Inhibitory Effect of n-hexane: ethyl Acetate fraction from Artemisia Vulgaris L. on Cell Culture of Oral Epithelial Carcinoma

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Sudamala herb (Artemisia vulgaris L) is often used in society as an anti tumor for organs of digestive system including oral cavity. Nevertheless, there are still no further scientific researches on active materials which can be used as anti curcinogen in oral covity. Most of anti carcinogents are actually obtained from the genus Artenisia. Mareover in Indonesia, the species of the genus artemisia that grows the most is Artemisia L. The problem of this research, however, is that the effect of n-hexane fraction ethyl acetate from Artemisia vulgaris L towards the decreasing of oncogene in oral squamous cell carcinoma is stillindefinate. The objective of this research is to explain the effect of giving n-hexane; ethyl acetate (3.7) fraction containing tempenoid from Artemisia vulgaris L towards the decreasing of oncogene in oral epithelial carcinoma cell line. The methodof this research is laboratoryexperimental resarch by using squanous cell carcinomia of oral cavity on cell culture. The inhibitory percentage test in vitro, furthemore, is taken during the analysis. The result then is analyzed by probit analysis with drawing relation curve between the inhibitory percentage and concentration. The result of n-hexane ; ethyl acetate (3-7) fraction containing terpenoid from Artemisia vulgaris L has the smallest IC50 µg/ml, lesss than 20 µg/ml saitable with NCI criteria; thus, it can potentially be used as anti carcinogen. There is the decreasing of oncogenes ofter being given n-hexane; Ethyl ocetate (3:7) , fraction containing terpenoid from Artemisia vulgaris L towards oral epithelial carcinoma cell line.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Dental Journal: 42(1):37-40

Penerbit

Surabaya : FKG Universitas Airlangga., 2009

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

1978-3728

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

CARCINOMA
ARTEMSIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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