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Perkembangan dan Konsep Imunologi Terkini dalam Patogenesis Psoriasis (Current Progress and Concept of Immunology in the Pathogenesis of Psoriasis)

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Psoriasis is a common chronic inflaramatory skin disorder that leads to considerable quality of life impairmentof the affected patients. Although the exact mecahnism of psoriasis is still unclear, the current understanding of genetic and immunology of the disease leads to an updated concept of the parthogenesis and advances in its treatment using biologic agents. This article describes the currents development and concept of the pathogenesis which is the framework of diagnosis and management of the patients. On going researches have nade important discoveries regarding the pathogenesis of psoriasis. Most important are regarding T helper (Th) 1 cells and other T-cells and ether T-cell population such as Th17 and regulatory T cells, dendritic cells, macrophages, the kreatinocyte signal transduction and novel cytokines including interleukin(IL)-17, IL-22 and IL-23. Each plays a specific role in the mechanism of the disease. The updated pathogenesis of psoriasis consists of district subsequent stages, in each of them different cell types playing a dominant role. The onset of the diseases is similar to an immune reaction, which is composed of three phases: a sensitization phase and an effector phase. Psoriasis is an immunologically inducted, overshot, regenertion like reaction of the skin in which different cells play a dominant role at a different stages.

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Series Title

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Call Number

Ilmu Kesehatan Kulit Kelamin: 21(3):206-212

Publisher

Surabaya : FK. Universitas Airlanggga., 2009

Collation

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Language

ISBN/ISSN

1978-4279

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Edition

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Subject(s)

allergy and immunology
PSIRIASIS

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