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Monositosis dan Limfositosis Merupakan Faktor Risiko Demam Berdarah Dengue pada Anak

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Dengue infection with its broad clinical spectrum remains a health problem in Indonesia. An aberrant immune response in plasma leakage of dengue hemorrhagic fever (DHF) caused by increase of monocytes and lymphocytes. The aim of this study was to investigate that monocytosis and lymphocytosis were risk factor of DHF in children. A case control study was conducted at Childe Health DepartmentHasan Sadikin General Hospital, Bandung from April to June 2009. Children aged ≤ 14 years who fulfilled the clinical criteria for dengue fever (DF) and dengue hemorrhagic fever (DHF), according to WHO (1997) confirmed with seroogic test. Monocytes and lymphocytes count were measured on admission. Data were analyzed using chi square test. Mann-Whitney test, and multiple logistic regression. The best cut-off point was determined using receiver operator characteristic (ROC) curve. All statistical computations were performed using SPSS 17.0 for Windows softwere. There were 50 DHF. The mem fever of monocytes dor DHF patients were 95.16/mm³ and 2,830.32/mm³;p96/mm³ and lymphocytes was > 1,472/mm³. Odds ratio (OR) of monocytosis (contfidence interval 95%) was 6.55:p=o.01 and OR of lymphocytosis was present, risk of DHF was 43.76. it is concluded that monocytosis and lymphocytosis are risk factors of DHF in children.

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Series Title

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Call Number

Majalah Kedokteran Bandung:41(4):201-206

Publisher

Bandung : FK Universitas Padjaran., 2009

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ISBN/ISSN

0126-074X

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Edition

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Subject(s)

child development
RSIK FACTOR
DENGUE HEMMORHAGIC VEVER

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