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Efek Terapi Citicoline terhadap Perbaikan Struktur dan Fungsi Membran Sel Otak pada Penderita Stroke

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Strokes lead to death or permanent disabilities for mellions for millions of people year when an interrruption of the flow of blood to brain cells deprives then of vital oxygen and nutrients. Deprivation of oxygen and nutrients. Deprivation on oxygen and nutrients results in a series in a sries of biochemical events, leading eventuall to cell death and often devestating functional neurological disturbances. Damaging and dying brain cels are very actively using an internal communications network. Most drugs work by interfering with molecules that play inportant roles within these networks. Citicoline is an assential intermediate in the biosynthesis of phasphatidylcholine, an imprtant component of the neural cell membrane as a part of internal communication network. Produced endogeneusly, citicoine serves as a ckoline donor in the metabolic pathways for biosynthesis of acetyclchoine and neuronal membrane phaspholipids, chiefly phasphatidylchoine. The principal components of citicoline, chhaline and cytidine, are readily absorbed in the GI tract and easly cross the blood brain barrier. Exagenous citicoline, has been researched in animal experiments and human clinical trials tat provide at its cholinergic and neuroprotective actions.

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Call Number

Medicinus:22(2):55-57

Publisher

Jakarta : Dexa Medica., 2009

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ISBN/ISSN

1979-391X

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Subject(s)

brain
CEREBROVASCULAR ACCIDENT

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