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Sub Chronic Toxicity Test From Alkohol Extract Paliasa Leaves (Kleinhovia Hospita Linn)mTo Hepar/Liver and Kindney of Experimental Mice

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Paliasa leaves used to be a traditional medicine for hepatic/ lever disease, so need to maintain the secure & health from the user of this medicine, the aim of the research is to find the dafa of ub chronic toxicity from 70% alcohol extract paliasa leaves for experimental mice. The research use amount 30 of 40 months whitemale mice wistar strain, which have weight in average (SD) about 208,75± 17,47 gr. The extract was given by oral through the spuit for 12 weeks (3 months) for every mice. After that, all of mice had been killed by ether liquid, and for histology examination, the blood had been teken from the mice’s heart liver & kidney.The research had been conduct with completed random design includes 5 treatment & 6 repeats. Each treatment includes give the mice aquades with dosage o mg/kg body weight (control) for 1 group paliasa leaves extract with dosage 250 mg/kg body weigt for 2 groups 3 group with dosage 500 mg/kg body wight 4 group with dosage 750 mg/kg body weight & for 5 group with dosage 1000 mg/kg body weight SGOT, SGPT, Bilirubin direct & indirect, creatinin, ureum kidney & liver cell destration had been measured from all of groups. The result shows that from eight parameters, in statistically, there are no significant differences between each treatment. The conclution is poliasa leaves extract still save in every treatment dosage.

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Series Title

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Call Number

Media Penelitian dan Pengembangan Kesehatan:19(4):

Publisher

Jakarta : Badan Penelitian dan Pengembangan Kesehatan., 2009

Collation

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Language

ISBN/ISSN

0853-9987

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Edition

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Subject(s)

mice
kidney failure, acute
PLANTS MEDICINAL
TOXICITY TESTS, CHRONIC

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