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Effects of BCG VaccinationPrior to Specifc Immunotherapy on IL-4/IFN- landa Ratio and AR Total Symptom Score in Persistent Allergi Rhinitis

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Allergic disease including allergic rhinitis (AR) is domited by Th₂responses with increased production of IL-4 and inhibition of IFN-ϒ production BCG vaccination induced IL-12 production which promotes. Th₀ to Th₁ shift and stimulates IFN-ϒ production. The aim of this study is to determine whether BCG vaccination prior specific immunotherapy (SIT) could increase initial phase of SIT responses measured by decreasing IL-4/IFN-ϒ ratio’s and AR total symptom score (TSS). This study was carried out by a randomzed controlled trial. A total of 84 patients with moderate to severe parsistent AR were randomized and assigned into 4 treatment group (BCG solvent, BCG vaccination, SIT, and BCG vaccination prior STT).A subcutaneous SIT was given using mised house dust mite extract (D pteronyssinus and D. Farinae, 50/50), while BCG vaccination was given by intraccutaneous injection. Clinical and concentrations of IL-4 and IFN-ϒ were measured by PHA stimulated fresh whole blood culture, before and after 8 weeks of SIT. There were no significance difference between the concentration of IL-4 and IFN-ϒ, and their ratio in all four groups. However, there is a significant lower IL-4/IFN-ϒ ratio in the group with preireatment of BCG than SIT (p=0.24), while during the initial phase, AR symptoms in patient who receivel BCG prior SIT is significantly lower than SIT 9p=0.027). The study demonstrates that BCG vaccination prior to SIT treatment could increase initial phase of SIT responses in persistent allergis rhinitis without additional adverse effects.

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Series Title

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Call Number

Media Medika Indonesiana:43(6):294-299

Publisher

Semarang : FK Diponegoro dan Ikatan Dokter Indonesia Jateng., 2009

Collation

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Language

English

ISBN/ISSN

0126-1762

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Edition

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Subject(s)

hypersensitivity
bcg vaccine
rhinitis

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