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Determination of L-Type Calcium Current in the Primary Hypertrophiel Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats /HHr

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The molecular mechanisms responsible for electronechanical derangements found in primary left venticular (LV) hypertrophy have not been clearly elucidated Of particular is the interest is the voltage gated L-type Ca curreent (Ica1) which plays crucial role in the EC-coupling. This study aimed to investigate cardiomuocyte Ica(1) in newly developed lime of rats namely HHR (hypertrophy have not been clearly elucidated Of particular interest is the voltage gated L-type Ca current (Ica1) which plays crucial role in the EC-coupling. This study aimed to investigate cardiomycocyte Ica(L) in newly developed line rats namely HHR(hypertrophy heart) and NHR (normal heart rat). A pure experimental study has been conducted using HHR (n=7 rats) and NHR (n=9 rats), aged 19-23 week cardiomycoctes were isolated enzymatically. By using whole cell patch clomp techniques, Lca wre measured and nomallized (pA/pE) for cell size determined by capacitance (Cm). In Nafree superfusfasate, the Ica(L) of HHR (n=18 cells) and NHR (n=12 cells) obtained at holding potential (HP)-50 mV were analyzed using Student’s t-test and one-way ANOVA (repeated measures). P

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Media Medika Indonesiana:43(6):269-276

Penerbit

Semarang : FK Diponegoro dan Ikatan Dokter Indonesia Jateng., 2009

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

0126-1762

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

HYPERTOOPHY, LEFT VEUBICULAR
MYOCYTES, CARDIAC

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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