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Prevalensi Kuman ESBL (Exrended Spectrum Beta Lactamase) dari Material Darah di RSUP Dr. Kariadi Tahun 2004-2005

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Prevalence of Extended-Spectrum β –Lactomases (ESBL)-bacteria of Blood Isolates in Dr. Kariadi Hospital Semarang 2004-2005. Prevalence of ESBL bacteria varies among hospitals, which its reistance could be spread to other bacteria : causes infections with a high morbidity and mortality. There were no data of ESBL prevalence and its distribution within Dr. Kariadi hospital wards. Objective of the study were to determine the prevalence, distribution and antibiotic senitivity pattern of ESBL, bacteria in Dr. Kariadi hospital. Retrospective study was used on laboratory records of in-patients at Clinical Microbiology Laboratory during 2004-2005. Blood culture was inoculated into BACTEC bottle medium, incubated at 27⁰C, isolated, identified and examined for antibiotic susceptibility by Kirby-Bauer method. Inclusion criteria were gram negative bacteria subjected to ESBL screening by cefotaxime, ceftazidime or ceftriaxone disc. Samples without clinical information were excluded. Afour thousand three hundred and fifty samples were examined during 2 years periode with culture positive rate was 34.70% consist of gram negative bacteria 59.6% in which ESBL bacteria was 50.6% ESBL bacteria significantly high recovered from intensive wards. Predominance bacteria were Ps. Aeruginosa (50.9%). E Aerogenes (37.5%) and E. Coli (8.7%). Sensitivity patterns to meropenem > 82.2%, quinolone > 65.6% Ps aeruginosa 52.5% fosfomisin > 74% except Ps. Aeruginosa 15.5%, amikacin > 82% except Ps. Aeruginosa 20.6%. Bacterial culture positive rate was 34.76% with predominance bacteria was gram negative bacteria (59.5%) in which ESBL detected in 50.6%. The most predominance bacteria were Ps. Aeruginosa, E. Aerogenes and E coli Antibiotic sensitivity patterns mostly sensitive to meropenem, aminoglycocide and quinolone.

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Media Medika Indonesiana:435):260-268

Publisher

Semarang : FK Diponegoro dan Ikatan Dokter Indonesia Jateng., 2009

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0126-1762

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infection
LETHAL DOSE 50

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